Analyse der Arzneimittelgesetze in Polen, Lettland und Malta unter besonderer Berücksichtigung des Parallelimports

Die EU-Erweiterungen der Jahre 2004 und 2007 stellten sowohl aufgrund der Zahl der beitretenden Länder als auch wegen der inhaltlichen Herausforderungen, die mit dem EU-Beitritt dieser Länder verbunden waren, ein völliges Novum dar. Das Ziel der Arbeit war die Untersuchung der arzneimittelrechtlichen Bestimmungen in den neuen Beitrittsländern Polen, Lettland und Malta, und eine Antwort auf die Frage, inwiefern diese in nationales Gesetz implementiert wurden und welche nationalen Regelungen sich auf den Wirkungsbereich des Parallelimports von Arzneimitteln erstrecken. Insbesondere wurden in diesem Zusammenhang die sozial-, patent-, marken- und kartellrechtlichen Bestimmungen erörtert. Neben dem Parallelimport standen der Import/Export von Arzneimitteln, der „Besondere Mechanismus“ und der Parallelvertrieb von zentral zugelassenen Arzneimitteln im Fokus der Betrachtung. Aufgrund der zurzeit gängigen Praxis des Umpackens  zugelassener Parallelimportarzneimittel wurde auch der Aspekt der Arzneimittelfälschungen mit aufgenommen und diskutiert. Die Ausgangssituationen der drei Beitrittsländer differierten sowohl untereinander als auch im Vergleich zu Deutschland. Polen, Lettland und Malta mussten daher unterschiedliche Leistungen zur Anpassung an die EU-rechtlichen Bestimmungen erbringen. Das Ergebnis zeigt, dass eine Harmonisierung bis zum Abschluss meiner Recherchen nicht erreicht war und die drei Länder bis dato noch einen unterschiedlichen Status aufweisen

Underlying Event measurements in pp collisions at s=0.9 \sqrt {s} = 0.9 and 7 TeV with the ALICE experiment at the LHC

We present measurements of Underlying Event observables in pp collisions at s√=0.9 and 7TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p T,LT in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p T thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2–3 between the lower and higher collision energies, depending on the track p T threshold considered. Data are compared to Pythia 6.4, Pythia 8.1 and Phojet. On average, all models considered underestimate the multiplicity and summed p T in the Transverse region by about 10–30%

Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.7Calouste Gulbenkian Foundation from LisbonSwiss Fonds Kidagan, ArmeniaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Financiadora de Estudos e Projetos (FINEP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)National Natural Science Foundation of China (NSFC)Chinese Ministry of Education (CMOE)Ministry of Science and Technology of China (MSTC)Ministry of Education and Youth of the Czech RepublicDanish Natural Science Research CouncilCarlsberg FoundationDanish National Research FoundationEuropean Research Council under European CommunityHelsinki Institute of PhysicsAcademy of FinlandFrench CNRS-IN2P3Region Pays de LoireRegion AlsaceRegion AuvergneCEA, FranceGerman BMBFHelmholtz AssociationGeneral Secretariat for Research and Technology, Ministry of Development, GreeceHungarian OTKANational Office for Research and Technology (NKTH)Department of Atomic EnergyDepartment of Science and Technology of the Government of IndiaIstituto Nazionale di Fisica Nucleare (INFN) of ItalyMEXT, JapanJoint Institute for Nuclear Research, DubnaNational Research Foundation of Korea (NRF)CONACYTDGAPA, MexicoALFA-ECHELEN Program (High-Energy physics Latin-American-European Network)Stichting voor Fundamenteel Onderzoek der Materie (FOM)Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), NetherlandsResearch Council of Norway (NFR)Polish Ministry of Science and Higher EducationNational Authority for Scientific Research - NASR (Autoritatea Nationala pentru Cercetare Stiintifica - ANCS)Federal Agency of Science of the Ministry of Education and Science of Russian FederationInternational Science and Technology Center, Russian Academy of SciencesRussian Federal Agency of Atomic EnergyRussian Federal Agency for Science and InnovationsCERN-INTASMinistry of Education of SlovakiaDepartment of Science and Technology, South AfricaCIEMATEELAMinisterio de Educacion y Ciencia of SpainXunta de Galicia (Conselleria de Educacion)CEADENCubaenergia, CubaIAEA (International Atomic Energy Agency)Swedish Reseach Council (VR)Knut & Alice Wallenberg Foundation (KAW)Ukraine Ministry of Education and ScienceUnited Kingdom Science and Technology Facilities Council (STFC)The United States Department of EnergyUnited States National Science FoundationState of TexasState of OhioFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

Centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb collisions at sNN\sqrt{s_{NN}} = 2.76 TeV

The centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb collisions at $\sqrt{s_{NN}}$ = 2.76 TeV is presented. The charged-particle density normalized per participating nucleon pair increases by about a factor 2 from peripheral (70-80%) to central (0-5%) collisions. The centrality dependence is found to be similar to that observed at lower collision energies. The data are compared with models based on different mechanisms for particle production in nuclear collisions.The centrality dependence of the charged-particle multiplicity density at mid-rapidity in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV is presented. The charged-particle density normalized per participating nucleon pair increases by about a factor 2 from peripheral (70-80%) to central (0-5%) collisions. The centrality dependence is found to be similar to that observed at lower collision energies. The data are compared with models based on different mechanisms for particle production in nuclear collisions

Measurement of charm production at central rapidity in proton-proton collisions at s\sqrt{s} = 2.76 TeV

The pt-differential production cross sections of the prompt (B feed-down subtracted) charmed mesons D0, D+, and D*+ in the rapidity range |y| K- pi+, D+ -> K- pi+ pi+, D*+ -> D0 pi+, and their charge conjugates, and was performed on a L_int = 1.1 nb^-1 event sample collected in 2011 with a minimum-bias trigger. The total charm production cross section at sqrt(s)= 2.76 TeV and at 7 TeV was evaluated by extrapolating to the full phase space the pt-differential production cross sections at sqrt(s) = 2.76 TeV and our previous measurements at sqrt(s) = 7 TeV. The results were compared to existing measurements and to perturbative-QCD calculations. The fraction of c dbar D mesons produced in a vector state was also determined.The $p_{\rm T}$-differential production cross sections of the prompt (B feed-down subtracted) charmed mesons D$^0$, D$^+$, and D$^{*+}$ in the rapidity range $|y|<0.5$, and for transverse momentum $1< p_{\rm T} <12$ GeV/$c$, were measured in proton-proton collisions at $\sqrt{s} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. The analysis exploited the hadronic decays D$^0 \rightarrow$K$\pi$, D$^+ \rightarrow$K$\pi\pi$, D$^{*+} \rightarrow$D$^0\pi$, and their charge conjugates, and was performed on a $L_{\rm int} = 1.1$ nb$^{-1}$ event sample collected in 2011 with a minimum-bias trigger. The total charm production cross section at $\sqrt{s} = 2.76$ TeV and at 7 TeV was evaluated by extrapolating to the full phase space the $p_{\rm T}$-differential production cross sections at $\sqrt{s} = 2.76$ TeV and our previous measurements at $\sqrt{s} = 7$ TeV. The results were compared to existing measurements and to perturbative-QCD calculations. The fraction of cdbar D mesons produced in a vector state was also determined

Measurement of the Cross Section for Electromagnetic Dissociation with Neutron Emission in Pb-Pb Collisions at √sNN = 2.76 TeV

The first measurement of neutron emission in electromagnetic dissociation of 208Pb nuclei at the LHC is presented. The measurement is performed using the neutron Zero Degree Calorimeters of the ALICE experiment, which detect neutral particles close to beam rapidity. The measured cross sections of single and mutual electromagnetic dissociation of Pb nuclei at √sNN = 2.76 TeV with neutron emission are σ_single EMD = 187.2±0.2 (stat.) +13.8−12.0 (syst.) b and σ_mutual EMD = 6.2 ± 0.1 (stat.) ±0.4 (syst.) b respectively. The experimental results are compared to the predictions from a relativistic electromagnetic dissociation model.The first measurement of neutron emission in electromagnetic dissociation of $^{208}$Pb nuclei at the LHC is presented. The measurement is performed using the neutron Zero Degree Calorimeters of the ALICE experiment, which detect neutral particles close to beam rapidity. The measured cross sections of single and mutual electromagnetic dissociation of Pb nuclei at $\sqrt{s_{\rm NN}}$ = 2.76 TeV with neutron emission are $\sigma_{\rm single\ EMD} = 187.4\pm0.2$ (stat.) $^{+13.2} _{-11.2}$ (syst.) b and $\sigma_{\rm mutual\ EMD} = 5.7\pm0.1$ (stat.) $\pm$0.4 (syst.) b, respectively. The experimental results are compared to the predictions from a relativistic electromagnetic dissociation model